Population genetics of Glutathione peroxidase (GPX1) in Central Portugal
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چکیده
منابع مشابه
Lack of the antioxidant glutathione peroxidase-1 (GPx1) exacerbates retinopathy of prematurity in mice.
PURPOSE Glutathione peroxidase-1 (GPx1) is highly expressed during normal retinal maturation; however, its role in retinopathy of prematurity (ROP) is not fully understood. We postulated that GPx1 plays an important role in protecting the premature retina from oxidative injury in a mouse model of ROP. METHODS ROP was induced in wild-type (WT) and GPx1 knockout (KO) mice by exposing neonatal m...
متن کاملLow glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from g-irradiation damage
Esworthy, R. Steven, Jeffrey R. Mann, Mindy Sam, and Fong-Fong Chu. Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from g-irradiation damage. Am J Physiol Gastrointest Liver Physiol 279: G426–G436, 2000.—Gpx1 knockout (KO) mice had a higher number of regenerating crypts in the jejunum than did Gpx2-KO or wild-type mice analyzed 4 days after $10 Gy g-irradiatio...
متن کاملPrognostic Significance of Glutathione Peroxidase Levels (GPx1) in Head and Neck Cancers
INTRODUCTION To date, no reliable prognostic biological marker for all squamous cell carcinoma located in different subsites of the head and neck region has been identified and used in daily routine. In line with our previous studies, in which we showed a role of glutathione and associated enzymes as potential biological markers, we investigated the relationship between GPx1 and prognosis of he...
متن کاملImmunolocalization of Glutathione-Peroxidase (GPx1) in the Rat Adrenal Cortex: Correlation between Steroidogenesis and Lipid Peroxidation
In order to confirm the relationship between glutathione-peroxidase (GPx1) and biological significance on steroidogenesis, we have studied the immunocytochemical localization of GPx1 in the rat adrenal cortical cells. GPx1 was observed not only in cytoplasm (cytosol GPx1) but in mitochondria (mitochondrial GPx1). The staining intensity was altered by the functional state of the adrenal cortical...
متن کاملLow glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage.
Gpx1 knockout (KO) mice had a higher number of regenerating crypts in the jejunum than did Gpx2-KO or wild-type mice analyzed 4 days after > or =10 Gy gamma-irradiation. Without gamma-irradiation, glutathione peroxidase (GPX) activity in the jejunal and ileal epithelium of Gpx1-KO mice was <10 and approximately 35%, respectively, of that of the wild-type mice. Four days after exposure to 11 Gy,...
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ژورنال
عنوان ژورنال: International Journal of Anthropology
سال: 1998
ISSN: 0393-9383,1824-3096
DOI: 10.1007/bf02442148